Odontogenic Keratocyst- The Controversies in Nomenclature and Treatment Modalities.

Summary: Odontogenic keratocysts (OKC) now officially known as Keratocystic odontogenic tumor (KCOT) is a benign odontogenic intraosseous tumor which is potentially agrressive having distinguished clinical and histopathological features. Based on a literature review, more aggressive treatment — either resection or enucleation supplemented with Carnoy’s solution with or without peripheral ostectomy — results in a lower recurrence rate than enucleation alone or marsupialization. WHO’s reclassification of this lesion from cyst to tumour underscores its aggressive nature and should motivate clinicians to manage the disease in a correspondingly aggressive manner. The purpose of this paper is to review and discuss the redesignation of KCOT and the implications for treatment.

Acute Lymphoblastic Leukemia with Treatment–Naïve Fanconi Anemia.

Fanconi anemia is known to have a predisposition to cancer, mostly associated with acute myeloid leukemia. We report an eight-year-old girl with treatment and naïve FA who developed acute-lymphoblastic-leukemia (ALL). She was initiated on chemotherapy but she failed to respond to treatment and died during induction phase of chemotherapy. While this association may be coincidental but possibility of transition of Fanconi anemia to ALL should be considered in view of high predisposition to cancer in this disorder.